Ethyl vinyl ether → 4-[1-(1-Ethoxy-ethoxy)-2-phenylethyl]cyclohexanone

HRID 2063718노트

반응식

HRID 2063718 반응식
[CH:1]([O:3][CH2:4][CH3:5])=[CH2:2].S(C1C=CC(C)=CC=1)([O-])(=O)=O.[NH+]1C=CC=CC=1.[OH:23][CH:24]([CH:32]1[CH2:37][CH2:36][C:35](=[O:38])[CH2:34][CH2:33]1)[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>C(Cl)Cl>[CH2:1]([O:3][CH:4]([O:23][CH:24]([CH:32]1[CH2:33][CH2:34][C:35](=[O:38])[CH2:36][CH2:37]1)[CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH3:5])[CH3:2]

참가 물질

5

반응물 3

HCID 8023Ethyl vinyl etherHCID 466102Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1)HCID 214336324-(1-Hydroxy-2-phenylethyl)cyclohexanone

생성물 1

HCID 668875294-[1-(1-Ethoxy-ethoxy)-2-phenylethyl]cyclohexanone

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

Ethyl vinyl ether (998 mg, 1.32 ml, 13.8 mmol) and pyridinium tosylate (44 mg, 0.17 mmol) were added to a solution of 4-(1-hydroxy-2-phenylethyl)cyclohexanone (2.52 g, 11.5 mmol) in anhydrous methylene chloride (50 ml) and the mixture was stirred at room temperature overnight. Methylene chloride (20 ml) was added to the mixture and the mixture was washed with water, 5% sodium bicarbonate solution and sodium chloride solution (50 ml of each). The combined organic phases were dried with sodium sulfate and concentrated i. vac.

후처리

  1. washthe mixture was washed with water, 5% sodium bicarbonate solution and sodium chloride solution (50 ml of each)
  2. dry with materialThe combined organic phases were dried with sodium sulfate
  3. concentrationconcentrated i

출처 및 근거

ORD 기록
ord-8c79fd8dea9c466884db519ac85f7bf5
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288406B2

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