3-Isoxazolamine → 1-Isoxazol-3-yl-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine

HRID 2063910노트

반응식

Cl[CH2:2][CH2:3][N:4]([CH2:19][CH2:20]Cl)[C:5]1[C:6]([CH3:18])=[C:7]([CH3:17])[C:8]2[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=2[C:15]=1[CH3:16].[O:22]1[CH:26]=[CH:25][C:24]([NH2:27])=[N:23]1>>[O:22]1[CH:26]=[CH:25][C:24]([N:27]2[CH2:20][CH2:19][N:4]([C:5]3[C:6]([CH3:18])=[C:7]([CH3:17])[C:8]4[O:12][C:11]([CH3:14])([CH3:13])[CH2:10][C:9]=4[C:15]=3[CH3:16])[CH2:3][CH2:2]2)=[N:23]1

참가 물질

반응물 2

HCID 18102163-Isoxazolamine

HCID 66760837N,N-bis(2-chloroethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine

생성물 1

HCID 594851331-Isoxazol-3-yl-4-(2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine수율 9%

실험 절차

By using N,N-bis(2-chloroethyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine (165 mg, 0.50 mmol) synthesized in Reference Example 146 and isoxazol-3-amine (0.044 mL, 0.60 mmol), the reaction was carried out in the same manner as Example 117 to obtain 15 mg of the title compound as a colorless solid (yield 9%).

출처 및 근거

ORD 기록: ord-d7ef289d9a044b62bef492405e026821
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08288390B2

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