Potassium Nitrate → 2-Chloro-4-fluoro-5-nitrobenzaldehyde
반응식
[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[CH:7]=[CH:6][C:3]=1[CH:4]=[O:5].[N+:11]([O-])([O-:13])=[O:12].[K+]>S(=O)(=O)(O)O>[Cl:1][C:2]1[CH:9]=[C:8]([F:10])[C:7]([N+:11]([O-:13])=[O:12])=[CH:6][C:3]=1[CH:4]=[O:5]참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
A stirred solution of 2-chloro-4-fluorobenzaldehyde (1.0 g, 6.3 mmol) in conc. sulphuric acid (8 ml) at 0° C. under argon was treated portionwise with potassium nitrate (0.70 g, 6.9 mmol) and maintained at 0° C. for 30 minutes, before warming to room temperature over 1.5 hrs. The reaction mixture was added to well stirred ice/water (100 ml) and then extracted with ethyl acetate. The extract was dried and concentrated to leave the title compound as a pale yellow oil (1.15 g, 90%).
후처리
- temperaturebefore warming to room temperature over 1.5 hrs
- extractionextracted with ethyl acetate
- customThe extract was dried
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-be49743bd7ff485f98a6c0651a56c04f
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08288412B2
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