Selectfluor → 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one

HRID 20642

반응식

HRID 20642 반응식
[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[O:5][C:4](=[O:20])[CH:3]=1.[B-](F)(F)(F)[F:22].[B-](F)(F)(F)F.C1[N+]2(CCl)CC[N+](F)(CC2)C1>C(#N)C>[NH2:1][C:2]1[C:11]2[C:6](=[C:7]([O:14][CH:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[C:8]([O:12][CH3:13])=[CH:9][CH:10]=2)[O:5][C:4](=[O:20])[C:3]=1[F:22]

참가 물질

4

반응물 2

HCID 2724933SelectfluorHCID 771747934-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

생성물 1

HCID 866181344-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A mixture of 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one (100 mg, 0.36 mmol, Example 3, Step 1), Selectfluor (160 mg, 0.45 mmol), and acetonitrile (1.5 mL) were stirred vigorously for 18 h, concentrated, and then purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one: MS (ESI): 294.0.

후처리

  1. concentrationconcentrated
  2. custompurified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate)

출처 및 근거

ORD 기록
ord-1f2b2ae8e5f1496aafb24688b567536b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745646B2

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