N,N-Dimethylaniline → HCID 25259881, 화합물

HRID 2064569노트

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HRID 2064569 반응식
[F:1][C:2]([F:25])([F:24])[C:3]1[CH:4]=[C:5]([CH:9]([O:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=CN=2)[C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[CH3:26][N:27](C)C1C=CC=CC=1.O1[CH2:40][CH2:39][N:38]([CH:41](O)[CH3:42])[CH2:37][CH2:36]1.[OH2:44]>O1CCCC1.CCOCC>[N:38]1([CH2:41][CH2:42][O:12][C:10](=[O:11])[CH:9]([C:5]2[CH:6]=[CH:7][CH:8]=[C:3]([C:2]([F:1])([F:25])[F:24])[CH:4]=2)[O:13][C:14]2[CH:26]=[N:27][C:17]([C:20]([F:21])([F:22])[F:23])=[CH:18][CH:19]=2)[CH2:39][CH2:40][O:44][CH2:36][CH2:37]1

참가 물질

7

반응물 4

HCID 949N,N-DimethylanilineHCID 962WaterHCID 30293761-MorpholinoethanolHCID 25259649(3-Trifluoromethyl-phenyl)-(5-trifluoromethyl-pyridin-2-yloxy)-acetic acid

생성물 1

HCID 25259881HCID 25259881, 화합물

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

실험 절차

(3-Trifluoromethyl-phenyl)-(5-trifluoromethyl-pyridin-2-yloxy)-acetic acid, 100, prepared as described in Example 4, (0.05 mol) was converted into the acid chloride, using the procedure of Example 6. The acid chloride (0.01 mol) was dissolved in tetrahydrofuran (25 mL) and N,N-dimethylaniline (2 mL) and morpholinoethanol (2 mL) were added. The progress of the reaction was monitored by TLC. When the reaction was complete, water and ether were added. The organic phase was washed with dilute hydrochloric acid, dried and concentrated. The residue was chromatographed to afford the title compound 137.

후처리

  1. washThe organic phase was washed with dilute hydrochloric acid
  2. customdried
  3. concentrationconcentrated
  4. customThe residue was chromatographed

출처 및 근거

ORD 기록
ord-a5e56f69397041739a93f9299d13f4f5
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288438B2

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