Cyclopropanecarbothioamide → 2-Cyclopropyl-5-p-tolyl-thiazole-4-carboxylic acid methyl ester

반응식

[CH3:1][O:2][C:3](=[O:15])[C:4](=O)[CH:5](Cl)[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1.[CH:16]1([C:19](=[S:21])[NH2:20])[CH2:18][CH2:17]1>>[CH3:1][O:2][C:3]([C:4]1[N:20]=[C:19]([CH:16]2[CH2:18][CH2:17]2)[S:21][C:5]=1[C:6]1[CH:11]=[CH:10][C:9]([CH3:12])=[CH:8][CH:7]=1)=[O:15]

참가 물질

반응물 2

HCID 22140884Cyclopropanecarbothioamide

HCID 57437153Methyl 3-chloro-2-oxo-3-(p-tolyl)propanoate

생성물 1

HCID 668667142-Cyclopropyl-5-p-tolyl-thiazole-4-carboxylic acid methyl ester

실험 절차

prepared by reaction of 3-chloro-2-oxo-3-p-tolyl-propionic acid methyl ester with cyclopropanecarbothioic acid amide. LC-MS: tR=1.04 min; [M+H]+=274.4.

출처 및 근거

ORD 기록: ord-bf4abdc7c0204170967d2730592ea9f4
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08288435B2

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