3,5-Dimethylisoxazole-4-carboxylic acid → (1S,3S,5S)-3-{[(3,5-dimethyl-isoxazole-4-carbonyl)-amino]-methyl}-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester
반응식
[C:1]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][NH2:15])[CH2:12][C@H:11]2[C@@H:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:16][C:17]1[C:21]([C:22](O)=[O:23])=[C:20]([CH3:25])[O:19][N:18]=1>>[C:1]([O:5][C:6]([N:8]1[C@H:13]([CH2:14][NH:15][C:22]([C:21]2[C:17]([CH3:16])=[N:18][O:19][C:20]=2[CH3:25])=[O:23])[CH2:12][C@H:11]2[C@@H:9]1[CH2:10]2)=[O:7])([CH3:4])([CH3:3])[CH3:2]참가 물질
3
실험 절차
prepared by reaction of (1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hexane-2-carboxylic acid tert-butyl ester with 3,5-dimethyl-isoxazole-4-carboxylic acid. LC-MS (acidic): tR=0.93 min; [M+H]+=336.2. 1H-NMR (CDCl3): δ=0.51 (bs, 1H); 0.81-0.87 (m, 1H); 1.49 (s, 9H); 1.50-1.56 (m, 1H); 1.74 (bd, J=13.5 Hz, 1H); 2.47 (s, 3H); 2.52-2.62 (m, 1H); 2.64 (s, 3H); 3.05-3.11 (m, 1H); 3.57-3.65 (m, 2H); 4.32-4.40 (m, 1H); 7.95 (bs, 1H).