2-Chloroaniline → 4-(2-Chlorophenylamino)-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

HRID 20648

반응식

HRID 20648 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].Cl[C:10]1[C:19]2[C:14](=[C:15]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[C:16]([O:20][CH3:21])=[CH:17][CH:18]=2)[O:13][C:12](=[O:28])[CH:11]=1>>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:10]1[C:19]2[C:14](=[C:15]([O:22][CH:23]3[CH2:27][CH2:26][CH2:25][CH2:24]3)[C:16]([O:20][CH3:21])=[CH:17][CH:18]=2)[O:13][C:12](=[O:28])[CH:11]=1

참가 물질

3

반응물 2

HCID 72402-ChloroanilineHCID 771747944-chloro-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

생성물 1

HCID 248495184-(2-Chlorophenylamino)-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

실험 절차

The title compound was prepared from 2-chloroaniline and 4-chloro-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one following the procedure outlined in Example 16. 1H NMR (400 MHz, DMSO-d6): δ 9.28 (s, 1H), 7.93 (d, 1H), 7.66 (d, 1H), 7.51-7.40 (m, 3H), 7.15 (d, 1H), 4.83 (m, 1H), 4.50 (s, 1H), 3.90 (s, 3H), 1.90-1.45 (m, 8H); MS (ESI): 385.9.

출처 및 근거

ORD 기록
ord-21e97f082af14a2ab98ae31140d9d558
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07745646B2

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