2-(3-chlorophenyl)benzoic Acid → benzofuran-4-carboxylic acid [(1S,3S,5S)-2-(3'-chloro-biphenyl-2-carbonyl)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide

HRID 2064820노트

반응식

HRID 2064820 반응식
[C@H:1]12[CH2:6][C@H:5]1[CH2:4][C@@H:3]([CH2:7][NH:8][C:9]([C:11]1[CH:12]=[CH:13][CH:14]=[C:15]3[O:19][CH:18]=[CH:17][C:16]=13)=[O:10])[NH:2]2.[Cl:20][C:21]1[CH:22]=[C:23]([C:27]2[C:28]([C:33](O)=[O:34])=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:24]=[CH:25][CH:26]=1>>[Cl:20][C:21]1[CH:22]=[C:23]([C:27]2[C:28]([C:33]([N:2]3[C@H:3]([CH2:7][NH:8][C:9]([C:11]4[CH:12]=[CH:13][CH:14]=[C:15]5[O:19][CH:18]=[CH:17][C:16]=45)=[O:10])[CH2:4][C@H:5]4[C@@H:1]3[CH2:6]4)=[O:34])=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:24]=[CH:25][CH:26]=1

참가 물질

3

반응물 2

HCID 27574152-(3-chlorophenyl)benzoic AcidHCID 67081492benzofuran-4-carboxylic acid [(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide

생성물 1

HCID 67081032benzofuran-4-carboxylic acid [(1S,3S,5S)-2-(3'-chloro-biphenyl-2-carbonyl)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide

실험 절차

prepared by reaction of benzofuran-4-carboxylic acid [(1S,3S,5S)-2-aza-bicyclo[3.1.0]hex-3-ylmethyl]-amide with 3′-chloro-biphenyl-2-carboxylic acid. LC-MS (basic): tR=1.46 min; [M+H]+=471.1.

출처 및 근거

ORD 기록
ord-e5a9b876be454362b7c18edfa6f527ec
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288435B2

반응 노트

불러오는 중…