1-Ethyl-3-methyl-1H-pyrazole-4-carboxylic acid → 1-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

HRID 2064872

반응식

HRID 2064872 반응식
[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH2:16])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1.[CH2:24]([N:26]1[CH:30]=[C:29]([C:31](O)=[O:32])[C:28]([CH3:34])=[N:27]1)[CH3:25]>>[NH2:1][C:2]1[S:3][C:4]([C:17]2[CH:22]=[CH:21][CH:20]=[C:19]([F:23])[CH:18]=2)=[C:5]([C:7]([N:9]2[C@H:14]([CH2:15][NH:16][C:31]([C:29]3[C:28]([CH3:34])=[N:27][N:26]([CH2:24][CH3:25])[CH:30]=3)=[O:32])[CH2:13][C@H:12]3[C@@H:10]2[CH2:11]3)=[O:8])[N:6]=1

참가 물질

3

반응물 2

HCID 10758811-Ethyl-3-methyl-1H-pyrazole-4-carboxylic acidHCID 86653658[2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone

생성물 1

HCID 866536631-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide

실험 절차

prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with 1-ethyl-3-methyl-1H-pyrazole-4-carboxylic acid. LC-MS (basic): tR=0.73 min; [M+H]+=469.2.

출처 및 근거

ORD 기록
ord-0fda5620d59c45dea25315e18e809669
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288435B2

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