Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Isoquinoline-1-carboxylic acid → isoquinoline-1-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Isoquinoline-1-carboxylic acid | HCID 68092 | — |
| 반응물 | [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone | HCID 86653658 | — |
| 생성물 | isoquinoline-1-carboxylic acid {(1S,3S,5S)-2-[2-amino-5-(3-fluoro-phenyl)-thiazole-4-carbonyl]-2-aza-bicyclo[3.1.0]hex-3-ylmethyl}-amide | HCID 86653665 | — |
반응 단계
prepared by reaction of [2-amino-5-(3-fluoro-phenyl)-thiazol-4-yl]-((1S,3S,5S)-3-aminomethyl-2-aza-bicyclo[3.1.0]hex-2-yl)-methanone with isoquinoline-1-carboxylic acid. LC-MS (basic): tR=0.84 min; [M+H]+=488.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08288435B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-750fe5d6bec44832b5e00ee66a28e591 |
| 출처 메모 | uspto-grants-2012_10 |