참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Vorinostat | HCID 5311 | — |
| 용매 | Water ethanol | HCID 19096565 | — |
| 생성물 | N-hydroxy-N'-phenyloctanediamide vorinostat | HCID 86620476 | — |
반응 단계
The seed slurry is prepared by combining vorinostat—fine dry cake (97.8-116.3 g, 0.37-0.44 mol) and 50:50 (v/v) ethanol/water solution (1.0-1.2 L). Under a minimum of 15 psig pressure, the seed slurry is heated to 62-66° C., aged for about 0.5 hours and then cooled to 60-64° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08288440B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_10 |
|---|
| ORD ID | ord-8abf0c6c44de43bab2ee6b1ad8691665 |
|---|
| 출처 메모 | uspto-grants-2012_10 |
|---|
