4-Methoxycinnamic Acid → (E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-(4-methoxy-phenyl)-acrylamide

반응식

[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]1.[CH3:15][O:16][C:17]1[CH:22]=[CH:21][C:20](/[CH:23]=[CH:24]/[C:25](O)=[O:26])=[CH:19][CH:18]=1>>[F:14][C:2]([F:1])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH:12][C:25](=[O:26])/[CH:24]=[CH:23]/[C:20]2[CH:21]=[CH:22][C:17]([O:16][CH3:15])=[CH:18][CH:19]=2)=[N:8]1

참가 물질

반응물 2

HCID 6994144-Methoxycinnamic Acid

HCID 669283041-(5,5-Difluoro-hexyl)-1H-pyrazol-3-ylamine

생성물 1

HCID 66929501(E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-(4-methoxy-phenyl)-acrylamide

실험 절차

Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-3-ylamine and (E)-3-(4-methoxy-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.08 min; [M+H]+=364.29.

출처 및 근거

ORD 기록: ord-d582e2054f0946af99fb699030353cd5
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08288419B2

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