m-(Trifluoromethyl)cinnamic acid → (E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-(3-trifluoromethyl-phenyl)-acrylamide

HRID 2065216

반응식

HRID 2065216 반응식
[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]1.[F:15][C:16]([F:29])([F:28])[C:17]1[CH:18]=[C:19](/[CH:23]=[CH:24]/[C:25](O)=[O:26])[CH:20]=[CH:21][CH:22]=1>>[F:14][C:2]([F:1])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH:12][C:25](=[O:26])/[CH:24]=[CH:23]/[C:19]2[CH:20]=[CH:21][CH:22]=[C:17]([C:16]([F:28])([F:29])[F:15])[CH:18]=2)=[N:8]1

참가 물질

3

반응물 2

HCID 719451m-(Trifluoromethyl)cinnamic acidHCID 669283041-(5,5-Difluoro-hexyl)-1H-pyrazol-3-ylamine

생성물 1

HCID 66929080(E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-(3-trifluoromethyl-phenyl)-acrylamide

실험 절차

Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-3-ylamine and (E)-3-(3-trifluoromethyl-phenyl)-acrylic acid. LC-MS-conditions 05b: tR=1.15 min; [M+H]+=402.06.

출처 및 근거

ORD 기록
ord-f5264fd17d3246c3949c6c7070b5d997
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288419B2

연결된 노트

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