3-Methylcinnamic acid → (E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-m-tolyl-acrylamide

반응식

[F:1][C:2]([F:14])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH2:12])=[N:8]1.[C:15]1([CH3:26])[CH:20]=[CH:19][CH:18]=[C:17](/[CH:21]=[CH:22]/[C:23](O)=[O:24])[CH:16]=1>>[F:14][C:2]([F:1])([CH3:13])[CH2:3][CH2:4][CH2:5][CH2:6][N:7]1[CH:11]=[CH:10][C:9]([NH:12][C:23](=[O:24])/[CH:22]=[CH:21]/[C:17]2[CH:16]=[C:15]([CH3:26])[CH:20]=[CH:19][CH:18]=2)=[N:8]1

참가 물질

반응물 2

HCID 20634483-Methylcinnamic acid

HCID 669283041-(5,5-Difluoro-hexyl)-1H-pyrazol-3-ylamine

생성물 1

HCID 66928909(E)-N-[1-(5,5-Difluoro-hexyl)-1H-pyrazol-3-yl]-3-m-tolyl-acrylamide

실험 절차

Following general procedure B, starting from 1-(5,5-difluoro-hexyl)-1H-pyrazol-3-ylamine and (E)-3-m-tolyl-acrylic acid. LC-MS-conditions 05b: tR=1.13 min; [M+H]+=348.31.

출처 및 근거

ORD 기록: ord-d54aae777f1f419db9317b7f12391144
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08288419B2

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