trans-2-Chloro-6-fluorocinnamic acid → (E)-3-(2-Chloro-6-fluoro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-acrylamide

HRID 2065218

반응식

HRID 2065218 반응식
[CH3:1][C:2]1([CH2:7][CH2:8][CH2:9][CH2:10][N:11]2[CH:15]=[C:14]([NH2:16])[CH:13]=[N:12]2)[O:6]CCO1.[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:19]=1/[CH:25]=[CH:26]/[C:27](O)=[O:28]>>[Cl:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:19]=1/[CH:25]=[CH:26]/[C:27]([NH:16][C:14]1[CH:13]=[N:12][N:11]([CH2:10][CH2:9][CH2:8][CH2:7][C:2](=[O:6])[CH3:1])[CH:15]=1)=[O:28]

참가 물질

3

반응물 2

HCID 5324668trans-2-Chloro-6-fluorocinnamic acidHCID 669287261-[4-(2-Methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine

생성물 1

HCID 66929528(E)-3-(2-Chloro-6-fluoro-phenyl)-N-[1-(5-oxo-hexyl)-1H-pyrazol-4-yl]-acrylamide

실험 절차

Following general procedure B followed by either C or D, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyl]-1H-pyrazol-4-ylamine and (E)-3-(2-chloro-6-fluoro-phenyl)-acrylic acid. LC-MS-conditions 01: tR=0.91 min; [M+H]+=364.10.

출처 및 근거

ORD 기록
ord-823fc841639c4025bc36a31c905e7abc
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288419B2

연결된 노트

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