2-Chloro-4-fluorocinnamic acid → (E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-chloro-4-fluoro-phenyl)-acrylamide

HRID 2065381

반응식

HRID 2065381 반응식
[CH3:1][C:2]1([C:7]2[N:8]=[C:9]([CH2:12][N:13]3[CH:17]=[CH:16][C:15]([NH2:18])=[N:14]3)[S:10][CH:11]=2)[O:6]CCO1.[Cl:19][C:20]1[CH:25]=[C:24]([F:26])[CH:23]=[CH:22][C:21]=1/[CH:27]=[CH:28]/[C:29](O)=[O:30]>>[C:2]([C:7]1[N:8]=[C:9]([CH2:12][N:13]2[CH:17]=[CH:16][C:15]([NH:18][C:29](=[O:30])/[CH:28]=[CH:27]/[C:21]3[CH:22]=[CH:23][C:24]([F:26])=[CH:25][C:20]=3[Cl:19])=[N:14]2)[S:10][CH:11]=1)(=[O:6])[CH3:1]

참가 물질

3

반응물 2

HCID 62572972-Chloro-4-fluorocinnamic acidHCID 66928995HCID 66928995, 화합물

생성물 1

HCID 66929404(E)-N-[1-(4-Acetyl-thiazol-2-ylmethyl)-1H-pyrazol-3-yl]-3-(2-chloro-4-fluoro-phenyl)-acrylamide

실험 절차

Following general procedure B followed by C, starting from 1-[4-(2-methyl-[1,3]dioxolan-2-yl)-thiazol-2-ylmethyl]-1H-pyrazol-3-ylamine and (E)-3-(2-chloro-4-fluoro-phenyl)-acrylic acid. LC-MS-conditions 05: tR=0.83 min; [M+H]+=404.9.

출처 및 근거

ORD 기록
ord-3df91ff317ef4ed888144904d6a46e3e
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288419B2

연결된 노트

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