Potassium Hydroxide → HCID 178517804, 화합물

HRID 2065504노트

반응식

HRID 2065504 반응식
[Cl:1][C:2]1[N:7]=[C:6](SC)[N:5]2[N:10]=[CH:11][N:12]=[C:4]2[CH:3]=1.[OH-:13].[K+]>CO>[Cl:1][C:2]1[N:7]=[C:6]([OH:13])[N:5]2[N:10]=[CH:11][N:12]=[C:4]2[CH:3]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 592990517-Chloro-5-methylsulfanyl-[1,2,4]triazolo[1,5-c]pyrimidine

생성물 1

HCID 178517804HCID 178517804, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

7-Chloro-5-methylsulfanyl-[1,2,4]triazolo[1,5-c]pyrimidine (181 mg, 0.91 mmol) was dissolved in MeOH (4 ml). 2N KOH (8 ml) was added and the mixture was stirred at reflux for 2 hours. The solvents were removed by a rotavap. The residue was added 4N HCl in dioxane and stirred for an hour before it was concentrated. Water was added and the mixture was extracted with DCM to give 7-Chloro-[1,2,4]triazolo[1,5-c]pyrimidin-5-ol (35 mg) as a solid. [M+H] calc'd for C5H3ClN4O, 171; found, 171.

후처리

  1. temperatureat reflux for 2 hours
  2. customThe solvents were removed by a rotavap
  3. additionThe residue was added 4N HCl in dioxane
  4. stirringstirred for an hour before it
  5. concentrationwas concentrated
  6. additionWater was added
  7. extractionthe mixture was extracted with DCM

출처 및 근거

ORD 기록
ord-b9d5c6fda8574a23b5a5ab973f34ae34
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288536B2

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