Dl-Tryptophan → 2-[1-Carboxy-2-(1H-indol-3-yl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid

HRID 2065591

반응식

HRID 2065591 반응식
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([C:28]([OH:30])=[O:29])[CH2:18][C:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[NH:21][CH:20]=1>>[C:28]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:18][C:19]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[NH:21][CH:20]=1)([OH:30])=[O:29]

참가 물질

3

반응물 2

HCID 1148Dl-TryptophanHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

생성물 1

HCID 452567022-[1-Carboxy-2-(1H-indol-3-yl)-ethylamino]-6-chloro-quinoline-3-carboxylic acid수율 42%

실험 절차

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-tryptophan to provide the title compound in 42% yield as yellow needles (recrystallization from isopropanol).

출처 및 근거

ORD 기록
ord-73afbdec5a5642eb980ff6e173105de3
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288549B2

연결된 노트

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