Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
DL-norvaline → 2-(1-Carboxy-butylamino)-6-chloro-quinoline-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | DL-norvaline | HCID 824 | — |
| 반응물 | Acetonitrile | HCID 6342 | — |
| 반응물 | 2,6-Dichloroquinoline-3-carboxylic acid | HCID 24266068 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(1-Carboxy-butylamino)-6-chloro-quinoline-3-carboxylic acid | HCID 45256873 | 15% |
반응 단계
In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-2-aminopentanoic acid to provide the title compound in 15% yield as yellow needles (flash chromatography on SiO2, eluent MeCN, H2O, AcOH-20, 1, 0.3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08288549B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-fe506c4b218f493383546404080c7ff9 |
| 출처 메모 | uspto-grants-2012_10 |