2-Phenylglycine → 2-[(Carboxy-phenyl-methyl)-amino]-6-chloro-quinoline-3-carboxylic acid

HRID 2065594

반응식

HRID 2065594 반응식
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[CH:16]1[CH:21]=[CH:20][C:19]([CH:22]([NH2:26])[C:23]([OH:25])=[O:24])=[CH:18][CH:17]=1>>[C:23]([CH:22]([NH:26][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[C:19]1[CH:18]=[CH:17][CH:16]=[CH:21][CH:20]=1)([OH:25])=[O:24]

참가 물질

3

반응물 2

HCID 38662-PhenylglycineHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

생성물 1

HCID 452568752-[(Carboxy-phenyl-methyl)-amino]-6-chloro-quinoline-3-carboxylic acid수율 33%

실험 절차

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-phenylglycine to provide the title compound in 33% yield as yellow needles (recrystallization from DMF/water).

출처 및 근거

ORD 기록
ord-4c4ba31ec50b4fb9a7bc0ee05d0fc958
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288549B2

연결된 노트

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