Homophenylalanine, DL- → 2-(1-Carboxy-3-phenyl-propylamino)-6-chloro-quinoline-3-carboxylic acid

HRID 2065615

반응식

HRID 2065615 반응식
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([C:26]([OH:28])=[O:27])[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>>[C:26]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)([OH:28])=[O:27]

참가 물질

3

반응물 2

HCID 102530Homophenylalanine, DL-HCID 242660682,6-Dichloroquinoline-3-carboxylic acid

생성물 1

HCID 452543792-(1-Carboxy-3-phenyl-propylamino)-6-chloro-quinoline-3-carboxylic acid수율 77%

실험 절차

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with DL-homophenylalanine to provide the title compound in 77% yield as yellow needles (recrystallization from EtOH).

출처 및 근거

ORD 기록
ord-75041df39ec84b729677ee3f518288c4
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288549B2

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