2-Amino-3-phenylpropanamide → 2-[1-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-ethylamino]-6-chloro-quinoline-3-carboxylic acid

HRID 2065630노트

반응식

HRID 2065630 반응식
Cl[C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1.[NH2:16][CH:17]([CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)[C:18]([NH2:20])=[O:19]>>[C:18]([CH:17]([NH:16][C:18]([CH:17]([NH:16][C:2]1[C:11]([C:12]([OH:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([Cl:15])[CH:8]=2)[N:3]=1)[CH2:21][C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)=[O:19])[CH2:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)(=[O:19])[NH2:20]

참가 물질

3

반응물 2

HCID 1940972-Amino-3-phenylpropanamideHCID 242660682,6-Dichloroquinoline-3-carboxylic acid

생성물 1

HCID 673598942-[1-(1-Carbamoyl-2-phenyl-ethylcarbamoyl)-2-phenyl-ethylamino]-6-chloro-quinoline-3-carboxylic acid

실험 절차

In close analogy to the procedure described in Example 1, 2,6-dichloroquinoline-3-carboxylic acid is reacted with 2-amino-3-phenyl-propionamide to give the title compound in moderate yield.

출처 및 근거

ORD 기록
ord-9872085d98a34e918eea93bb7dfd1bad
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288549B2

반응 노트

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