6-Bromo-2-chloroquinoline-3-carboxylic acid → 6-Bromo-2-{2-[4-(5-bromo-pyridin-2-yloxy)-phenyl]-1-carboxy-ethylamino}-quinoline-3-carboxylic acid
반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7](Cl)[C:6]([C:13]([OH:15])=[O:14])=[CH:5]2.[NH2:16][CH:17]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([O:28][C:29]2[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][N:30]=2)=[CH:24][CH:23]=1)[C:18]([OH:20])=[O:19]>>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([NH:16][CH:17]([C:18]([OH:20])=[O:19])[CH2:21][C:22]1[CH:23]=[CH:24][C:25]([O:28][C:29]3[CH:34]=[CH:33][C:32]([Br:35])=[CH:31][N:30]=3)=[CH:26][CH:27]=1)[C:6]([C:13]([OH:15])=[O:14])=[CH:5]2참가 물질
3
실험 절차
In close analogy to the procedure described in Example 109c, 6-bromo-2-chloroquinoline-3-carboxylic acid is reacted with 2-amino-3-[4-(5-bromo-pyridin-2-yloxy)-phenyl]-propionic acid (prepared by analogy to Example 109a,b) to provide the title compound in moderate yield.
출처 및 근거
- ORD 기록
- ord-4482a9f89df548a2bf57d8b5b6dee41d
- 출처 데이터셋
- uspto-grants-2012_10