Cyclohexyl isocyanate → HCID 131730023, 화합물
반응식
[OH:1][CH:2]([CH3:10])/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6].[CH:11]1([N:17]=[C:18]=[O:19])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[CH:11]1([NH:17][C:18]([O:1][CH:2]([CH3:10])/[CH:3]=[CH:4]/[C:5]([O:7][CH2:8][CH3:9])=[O:6])=[O:19])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1참가 물질
4
실험 절차
Reaction of 21 (rac-Ethyl (2E)-4-hydroxypent-2-enoate) (1.44 g, 10 mmol) with cyclohexyl isocyanate (2.53 ml, 20 mmol) in toluene (8 ml) according to Example 1. Purification by flash chromatography (AcOiPr:heptane fraction 15:85 to 25:75) yields 5 (rac-Ethyl (2E)-4-(cyclohexylaminocarbonyloxy)pent-2-enoate) (2.29 g, 85%) as a yellowish solid.
후처리
- customPurification by flash chromatography (AcOiPr:heptane fraction 15:85 to 25:75)
출처 및 근거
- ORD 기록
- ord-3ddc44bb33914b10b720f62b529c7b4e
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08288566B2
반응 노트
불러오는 중…