Trifluoroacetic acid → 3-(Hydroxymethyl)azetidine trifluoroacetate

HRID 2066273노트

반응식

HRID 2066273 반응식
[OH:1][CH2:2][CH:3]1[CH2:6][N:5](C(OC(C)(C)C)=O)[CH2:4]1.[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17]>>[F:14][C:15]([F:20])([F:19])[C:16]([OH:18])=[O:17].[OH:1][CH2:2][CH:3]1[CH2:6][NH:5][CH2:4]1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 10583745tert-Butyl 3-(hydroxymethyl)azetidine-1-carboxylate

생성물 1

HCID 685001703-(Hydroxymethyl)azetidine trifluoroacetate

실험 절차

To tert-butyl 3-(hydroxymethyl)azetidine-1-carboxylate (125 mg) was added trifluoroacetic acid (0.413 ml) while cooling in an ice bath, followed by stirring at the same temperature for 30 min. Then, the reaction mixture was stirred at room temperature for 1.5 hr. The reaction mixture was concentrated to provide a crude product of the titled compound as a yellow oil (209.8 mg).

후처리

  1. temperaturewhile cooling in an ice bath
  2. stirringThen, the reaction mixture was stirred at room temperature for 1.5 hr
  3. concentrationThe reaction mixture was concentrated

출처 및 근거

ORD 기록
ord-f55fba82ad1e4096990f4d9d723f1410
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08288538B2

반응 노트

불러오는 중…