Water → 6-(Trifluoroacetamido)-1-hexanol

HRID 2066375노트

반응식

HRID 2066375 반응식
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8].[F:9][C:10]([F:17])([F:16])[C:11](OCC)=[O:12].O>ClCCl>[F:9][C:10]([F:17])([F:16])[C:11]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][OH:8])=[O:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 9794Ethyl trifluoroacetateHCID 199606-Amino-1-hexanol

생성물 1

HCID 36276076-(Trifluoroacetamido)-1-hexanol

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

6-aminohexanol (11.7 g; 100 mmol) is dissolved in dry dichloromethane (100 mL) and drop wise added ethyl trifluoroacetate (15 g; 105 mmol) in dry dichloromethane (50 mL) (˜30 min), and the mixture is stirred overnight. Water (10 ml) is added, and the mixture is stirred for 30 min. The solution is washed with water (2×100 mL), dried (Na2SO4), and concentrated. The residue is redissolved in acetonitrile (100 μL) and concentrated. The residue is placed on vacuum overnight, and a white crystalline solid is obtained. Yield 19 g.

후처리

  1. stirringthe mixture is stirred for 30 min
  2. washThe solution is washed with water (2×100 mL)
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated
  5. dissolutionThe residue is redissolved in acetonitrile (100 μL)
  6. concentrationconcentrated
  7. customis placed on vacuum overnight
  8. customa white crystalline solid is obtained

출처 및 근거

ORD 기록
ord-e12b45d1c0064b6499d8d90420df1902
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293684B2

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