Water → HCID 67387610, 화합물

HRID 2066378노트

반응식

HRID 2066378 반응식
[OH:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[OH:12].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+].O>CC(C)=O.C(OCC)(=O)C>[CH2:13]([O:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]=[CH:4][C:3]=1[OH:12])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

7

반응물 4

HCID 962WaterHCID 7498Benzyl BromideHCID 113181,2-DihydroxynaphthaleneHCID 11430Potassium Carbonate

생성물 1

HCID 67387610HCID 67387610, 화합물수율 18.9%

시약·촉매·용매 2

HCID 180Acetone용매HCID 8857Ethyl Acetate용매

반응 조건

온도
70 °C

실험 절차

1,2-Dihydroxynaphthalene (70 mg) was dissolved in acetone (1 ml), the solution was added with benzyl bromide (74.7 mg) and potassium carbonate (72.5 mg), and the mixture was stirred at 70° C. for 1 hour. The reaction mixture was added with distilled water and ethyl acetate, the layers were separated, and the organic layer was dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:acetone:triethylamine=50:10:0.2) to obtain the title compound (20.7 mg).

후처리

  1. customthe layers were separated
  2. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated under reduced pressure
  5. customthe resulting residue was purified by silica gel column chromatography (hexane:acetone:triethylamine=50:10:0.2)

출처 및 근거

ORD 기록
ord-50318c999f944bf1960f183bc0f4f14b
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293715B2

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