Benzene, 1-bromo-3-iodo- → 2-(3-Bromophenyl)furan

온도

45 °C

1-Bromo-3-iodobenzene (3.0 g), tris(dibenzylideneacetone)dipalladium(0) (1.22 g), tributyl(furan-2-yl)tin (3.34 ml), and tri(o-tolyl)phosphine (807 mg) were dissolved in dioxane (30 ml), and the solution was stirred at room temperature for 20 hours, at 35° C. for 6 hours, at 45° C. for 19 hours, and at 55° C. for 5 hours and 30 minutes. The reaction mixture was filtered through Celite, the filtrate was concentrated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (NH-form, hexane) to obtain the title compound (1.40 g).

1. waitat 55° C. for 5 hours
2. custom30 minutes
3. filtrationThe reaction mixture was filtered through Celite
4. concentrationthe filtrate was concentrated under reduced pressure
5. customthe resulting residue was purified by silica gel column chromatography (NH-form, hexane)

ORD 기록

ord-59f99089eb154c02922740a4e714ff08

출처 데이터셋

uspto-grants-2012_10

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08293715B2