3-Hydroxyacetophenone → 3-(2-Hydroxypropan-2-yl)phenol
반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[CH3:11][Mg]Br.[Cl-].[NH4+]>O1CCCC1.C(OCC)C>[OH:10][C:8]([C:4]1[CH:3]=[C:2]([OH:1])[CH:7]=[CH:6][CH:5]=1)([CH3:11])[CH3:9]참가 물질
6
실험 절차
3′-Hydroxyacetophenone (500 mg) was dissolved in tetrahydrofuran (10 ml), and the solution was slowly added dropwise with a 3 M solution of methylmagnesium bromide in diethyl ether (3.7 ml) under ice cooling. The mixture was stirred at the same temperature for 2 hours, and then added with saturated aqueous ammonium chloride, the mixture was extracted with ethyl acetate, and the organic layer was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=5:1 to 1:1) to obtain the title compound (224.3 mg).
후처리
- extractionthe mixture was extracted with ethyl acetate
- concentrationthe organic layer was concentrated under reduced pressure
- customThe resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=5:1 to 1:1)
출처 및 근거
- ORD 기록
- ord-39c07a8b5ee34016b3b834139786b5f3
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08293715B2
반응 노트
불러오는 중…