Benzoyl Peroxide → HCID 59151288, 화합물

HRID 2066452노트

반응식

HRID 2066452 반응식
[Br:1][C:2]1[C:3]([CH3:15])=[C:4]([NH:8][C:9](=[O:14])[C:10]([F:13])([F:12])[F:11])[CH:5]=[CH:6][CH:7]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.[Br:34]Br>C(Cl)(Cl)(Cl)Cl.C(Cl)Cl.[W]>[Br:1][C:2]1[C:3]([CH2:15][Br:34])=[C:4]([NH:8][C:9](=[O:14])[C:10]([F:11])([F:13])[F:12])[CH:5]=[CH:6][CH:7]=1

참가 물질

7

반응물 3

HCID 7187Benzoyl PeroxideHCID 24408BromineHCID 86638092Acetamide, N-(3-bromo-2-methylphenyl)-2,2,2-trifluoro-

생성물 1

HCID 59151288HCID 59151288, 화합물

시약·촉매·용매 3

HCID 23964Tungsten촉매HCID 5943Carbon Tetrachloride용매2회HCID 6344Dichloromethane용매

실험 절차

A solution of N-(3-bromo-2-methyl-phenyl)-2,2,2-trifluoro-acetamide (2.1 g, 7.4 mmol) and benzoyl peroxide (100 mg) in carbon tetrachloride (50 mL) was heated to reflux under irradiation (150 W tungsten lamp). A solution of bromine (0.55 mL, 10.4 mmol) in carbon tetrachloride (3 mL) was then added drop-wise to the refluxing solution, and heating was pursued for 16 h. The reaction mixture was left to cool to RT and diluted with DCM. The organic layer was washed with sodium thiosulfate, and evaporated to dryness to give N-(3-bromo-2-bromomethyl-phenyl)-2,2,2-trifluoro-acetamide as a brown residue which was used without further purification (2.9 g).

후처리

  1. temperatureheating
  2. waitThe reaction mixture was left
  3. washThe organic layer was washed with sodium thiosulfate
  4. customevaporated to dryness

출처 및 근거

ORD 기록
ord-1fd1dad8937b47299086ac687cbdccca
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293735B2

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