Isopropanol → (9aR)-octahydropiperazino[2,1-c]morpholine
반응식
[CH2:1]1[C@H:6]2[CH2:7][NH:8][CH2:9][CH2:10][N:5]2[C:4](=O)[CH2:3][O:2]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].CC(O)C.[O-]S([O-])(=O)=O.[Na+].[Na+]>O1CCOCC1>[CH2:1]1[C@H:6]2[CH2:7][NH:8][CH2:9][CH2:10][N:5]2[CH2:4][CH2:3][O:2]1참가 물질
6
실험 절차
To a solution of (R)-hexahydro-pyrazino[2,1-c][1,4]oxazin-4-one (60 mg, 0.39 mmol) in dioxane (5 mL) was added LiAlH4 (1.5 mL, 1M solution in THF). The resulting mixture was heated at 80° C. for 2.5 h before the addition of iPrOH (0.5 mL) followed by a saturated aqueous solution of Na2SO4 (3 mL). Further Na2SO4 was added and the resulting mixture filtered through celite, washing with EtOAc. The resulting residue was purified by NH2 column to give the title compound as an oil (40 mg, 73%).
후처리
- filtrationthe resulting mixture filtered through celite
- washwashing with EtOAc
- customThe resulting residue was purified by NH2 column
출처 및 근거
- ORD 기록
- ord-0de7cf8cbd134b419f5ede457cf48a8c
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08293735B2
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