Tert-butyl octahydropyrrolo(3,4-c)pyrrole-2-carboxylate → 2-(6-Fluoro-1H-indol-4-yl)-6-(hexahydro-pyrrolo[3,4-c]pyrrol-2-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

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[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[C:4]([C:11]2[N:12]=[C:13]([N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)[C:14]3[S:19][C:18]([CH2:20][N:21]4[CH2:26][C@@H]5CCCN5C[CH2:22]4)=[CH:17][C:15]=3[N:16]=2)[CH:3]=1.C(OC([N:43]1[CH2:50][CH:49]2[CH:45](CNC2)[CH2:44]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O.C(Cl)Cl>>[F:1][C:2]1[CH:10]=[C:9]2[C:5]([CH:6]=[CH:7][NH:8]2)=[C:4]([C:11]2[N:12]=[C:13]([N:30]3[CH2:35][CH2:34][O:33][CH2:32][CH2:31]3)[C:14]3[S:19][C:18]([CH2:20][N:21]4[CH2:22][CH:49]5[CH:45]([CH2:44][NH:43][CH2:50]5)[CH2:26]4)=[CH:17][C:15]=3[N:16]=2)[CH:3]=1