참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Chloro-4-fluoro-1-nitrobenzene | HCID 75017 | — |
| 반응물 | 1-Ethylpiperazine | HCID 79196 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(3-Chloro-4-nitro-phenyl)-4-ethyl-piperazine | HCID 69161998 | 72.6% |
반응 단계
N-Ethylpiperazine (4.3 mL, 34.3 mmol, 1.2 equiv) is added to a mixture of 2-chloro-4-fluoronitrobenzene (5 g, 28.6 mmol) and potassium carbonate (7.9 g, 57.1 mmol, 2 equiv) in DMF (50 mL). The reaction mixture is stirred at 100° C. for 6 h, allowed to cool to RT, diluted with H2O and extracted with EtOAc. The organic phase is washed with brine, dried (Na2SO4), filtered and concentrated. The residue is purified by trituration in diethyl ether to provide 5.6 g of the title compound as a yellow solid: ES-MS: 270.0 [MH]+; tR=2.90 min (system 1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08293746B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_10 |
|---|
| ORD ID | ord-7f3ed84487a84cc8b8108bf20cbcd052 |
|---|
| 출처 메모 | uspto-grants-2012_10 |
|---|
