Ethyl isocyanate → HCID 58333511, 화합물

HRID 2066845노트

반응식

HRID 2066845 반응식
[CH:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([O:13][N:14]=[C:15]2[CH2:20][CH2:19][N:18]([C:21]3[CH:26]=[C:25]([F:27])[C:24]([CH2:28][NH2:29])=[CH:23][C:22]=3[F:30])[CH2:17][CH2:16]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2].C(N(CC)CC)C.[CH2:38]([N:40]=[C:41]=[O:42])[CH3:39]>C(Cl)Cl>[CH:1]([O:4][C:5]([N:7]1[CH2:12][CH2:11][CH:10]([O:13][N:14]=[C:15]2[CH2:16][CH2:17][N:18]([C:21]3[CH:26]=[C:25]([F:27])[C:24]([CH2:28][NH:29][C:41]([NH:40][CH2:38][CH3:39])=[O:42])=[CH:23][C:22]=3[F:30])[CH2:19][CH2:20]2)[CH2:9][CH2:8]1)=[O:6])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 8022Ethyl isocyanateHCID 8471TriethylamineHCID 86655007HCID 86655007, 화합물

생성물 1

HCID 58333511HCID 58333511, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 16a (23 mg) and triethylamine (0.1 mL) in 1 mL of DCM was added a drop of ethyl isocyanate (excess) and the reaction mixture was stirred for 30 minutes at room temperature. The mixture was then quenched with water and extracted with DCM to give 33 mg of crude product which was purified on preparative HPLC to give 16-1: LC-MS 496.2 (MH+).

후처리

  1. customThe mixture was then quenched with water
  2. extractionextracted with DCM

출처 및 근거

ORD 기록
ord-9524d7c84d23434a91f7a535c3f5cd4a
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293729B2

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