Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2066863생성일: 2026년 10월 27일
Ethyl Acetate → 4-(3'-Fluoro-5'-formyl-2,3,5,6-tetrahydro-[1,2]bipyridinyl-4-ylideneaminooxy)-piperidine-1-carboxylic acid isopropyl ester
https://huagongshe.com/reaction/2066863
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 6-Chloro-5-fluoropyridine-3-carbaldehyde | HCID 21698194 | — |
| 반응물 | Isopropyl 4-(Piperidin-4-ylideneaminooxy)piperidine-1-carboxylate | HCID 57461147 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 4-(3'-Fluoro-5'-formyl-2,3,5,6-tetrahydro-[1,2]bipyridinyl-4-ylideneaminooxy)-piperidine-1-carboxylic acid isopropyl ester | HCID 86655011 | — |
반응 단계
2d (0.45 g, 1.6 mmol), 6-chloro-5-fluoro-pyridine-3-carbaldehyde 53a (0.6 g, 3.76 mmol) and diisopropylethylamine (0.75 mL, 4.5 mmol) were combined in 5 mL of DMSO and heated at 60° C. for 18 h. The mixture was poured into ethyl acetate (30 mL), washed with water (2×20 mL) and brine (2×20 mL) and concentrated to give the crude 53b.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08293729B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_10 |
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| ORD ID | ord-ba959599cd8c4c419297824a9edb996d |
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| 출처 메모 | uspto-grants-2012_10 |
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