Triethylamine → HCID 58333576, 화합물

HRID 2066889노트

반응식

HRID 2066889 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([O:7][N:8]=[C:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:23])=[O:22])=[CH:17][C:16]=3[F:25])[CH2:11][CH2:10]2)[CH2:3][CH2:2]1.[CH3:26][N:27]1[CH:31]=[CH:30][CH:29]=[C:28]1[CH:32]=O.C(N(CC)CC)C.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>C(Cl)Cl>[CH3:26][N:27]1[CH:31]=[CH:30][CH:29]=[C:28]1[CH2:32][N:1]1[CH2:6][CH2:5][CH:4]([O:7][N:8]=[C:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:20]=[CH:19][C:18]([S:21]([CH3:24])(=[O:22])=[O:23])=[CH:17][C:16]=3[F:25])[CH2:11][CH2:10]2)[CH2:3][CH2:2]1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 145041-Methyl-1H-pyrrole-2-carbaldehydeHCID 5049666Sodium triacetoxyborohydrideHCID 866550221-(2-Fluoro-4-methanesulfonyl-phenyl)-piperidin-4-one O-piperidin-4-yl-oxime

생성물 1

HCID 58333576HCID 58333576, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To 63a (24 mg, 0.065 mmol) in 1 mL of DCM, was added 1-methyl-1H-pyrrole-2-carbaldehyde (10.6 g, 0.098 mmol), triethylamine (27 μL, 0.19 mmol) and sodium triacetoxyborohydride (27.6 mg, 0.13 mmol). The mixture was stirred overnight at room temperature, concentrated and purified on preparative HPLC to give 66-1: LC-MS 463.0 (MH+).

후처리

  1. concentrationconcentrated
  2. custompurified on preparative HPLC
  3. customto give 66-1

출처 및 근거

ORD 기록
ord-c87e000c38be41bc9b806b2e3bd7d6ae
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293729B2

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