Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl 5-amino-3-methylthiophene-2,4-dicarboxylate → 2-(2-Benzyloxycarbonylaminoethyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl 5-amino-3-methylthiophene-2,4-dicarboxylate | HCID 78537 | — |
| 반응물 | benzyl N-(2-cyanoethyl)carbamate | HCID 262127 | — |
| 생성물 | 2-(2-Benzyloxycarbonylaminoethyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid | HCID 69077067 | — |
반응 단계
Using diethyl 5-amino-3-methylthiophene-2,4-dicarboxylate and benzyl N-(2-cyanoethyl)carbamate, the ring-closing reaction was carried out similarly to Production Example 1. Successively the hydrolysis was carried out similarly to Example 1, to provide 2-(2-benzyloxycarbonylaminoethyl)-5-methyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08293754B2 |
| 출처 데이터셋 | uspto-grants-2012_10 |
| ORD ID | ord-688097459afe475a94f7ce25b7f965aa |
| 출처 메모 | uspto-grants-2012_10 |