Tetrahydrofuran → HCID 21989976, 화합물

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[OH:9].[O:10]1CCC[CH2:11]1>>[F:8][C:4]1[C:3]2[O:9][C:11](=[O:10])[NH:1][C:2]=2[CH:7]=[CH:6][CH:5]=1

참가 물질

반응물 2

HCID 8028Tetrahydrofuran

HCID 6435622-Amino-6-fluorophenol

생성물 1

HCID 21989976HCID 21989976, 화합물

실험 절차

In a three neck flask, fitted with a magnetic stirrer, under inert atmosphere, 1,1-carbonyldiimidazole (15.6 g, 96 mmol) is added to a solution of 2-amino-6-fluorophenol 1 (4 g, 32 mmol) in 100 ml of anhydrous tetrahydrofuran at room temperature. The solution is refluxed for 1 h, cooled down to room temperature and concentrated in vacuo. The crude reaction mixture is purified by chromatography on silicagel (n-hexane/AcOEt:1/1 (v/v)) to afford 7-fluoro-1,3-benzoxazol-2(3H)-one 2.

후처리

temperatureThe solution is refluxed for 1 h
concentrationconcentrated in vacuo
customThe crude reaction mixture
customis purified by chromatography on silicagel (n-hexane/AcOEt:1/1 (v/v))

출처 및 근거

ORD 기록: ord-28a46127a9ea475185c9b8227f5649ed
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08293775B2

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