Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2067131생성일: 2026년 10월 27일
Potassium Carbonate → 4-Chloro-5-[1,3]dioxolan-2-yl-6-(4-[1,2,3]thiadiazol-4-yl-phenoxy)-pyrimidine
https://huagongshe.com/reaction/2067131
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-(1,2,3-Thiadiazol-4-Yl)Phenol | HCID 2796860 | — |
| 반응물 | 4,6-Dichloro-5-(1,3-dioxolan-2-yl)pyrimidine | HCID 59594440 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 4-Chloro-5-[1,3]dioxolan-2-yl-6-(4-[1,2,3]thiadiazol-4-yl-phenoxy)-pyrimidine | HCID 86607980 | — |
반응 단계
To a mixture of 4,6-dichloro-5-[1,3]dioxolan-2-yl-pyrimidine (100.0 mg, 0.45 mmol) and added Potassium Carbonate (80.62 mg, 0.45 mmol) in DMF (5 mL) cooled to 0° C. was added a solution of 4-[1,2,3]-thiadiazol-4-yl-phenol (DMF) drop wise. The resulting mixture was stirred at room temperature for 30 minutes to give 4-chloro-5-[1,3]dioxolan-2-yl-6-(4-[1,2,3]thiadiazol-4-yl-phenoxy)-pyrimidine. LCMS (ESI) for C15H11ClN4O3S: m/z 362.9 (M+H+, 100%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08293751B2 |
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| 출처 데이터셋 | uspto-grants-2012_10 |
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| ORD ID | ord-2f0275702e394a64b5c2a8bb1d5aeedd |
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| 출처 메모 | uspto-grants-2012_10 |
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