Thionyl Chloride → 3-Chloroisonicotinoyl chloride hydrochloride

HRID 2067183노트

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HRID 2067183 반응식
[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].S(Cl)([Cl:13])=O>C1(C)C=CC=CC=1>[ClH:1].[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([Cl:13])=[O:5]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 27358163-Chloropyridine-4-carboxylic acid

생성물 1

HCID 866418943-Chloroisonicotinoyl chloride hydrochloride

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
100 °C

실험 절차

To a suspension of 3-chloroisonicotinic acid (750 mg, 4.76 mmol, 1.0 eq) in 25 mL of toluene was added thionyl chloride (3.0 mL, 41.6 mmol, 8.7 eq) at room temperature. The reaction mixture was stirred at 100° C. for 3 hours. The mixture was concentrated under reduced pressure, dissolved in 25 mL of toluene and concentrated again to give crude 3-chloroisonicotinoyl chloride hydrochloride salt, which was used in the next step without further purification.

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. dissolutiondissolved in 25 mL of toluene
  3. concentrationconcentrated again

출처 및 근거

ORD 기록
ord-a2dcbbe64fab4a199e4686f9206545c4
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293769B2

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