Potassium Carbonate → HCID 58677657, 화합물

HRID 2067191노트

반응식

HRID 2067191 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[C:26][Si](C)(C)C)[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18].C([O-])([O-])=O.[K+].[K+].CCOC(C)=O.O>CO>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]#[CH:26])[CH:22]=[CH:21][C:20]=1[CH3:31])=[O:18]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 22728543Water ethylacetateHCID 67314552HCID 67314552, 화합물

생성물 1

HCID 58677657HCID 58677657, 화합물

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of compound 406 (426 mg, 0.94 mmol) and K2CO3 (195 mg, 1.41 mmol) in methanol (4.0 mL) were stirred at RT for 5 h. The reaction mixture was poured into a mixture of EtOAc/water. The organic phase was washed with water, brine and then dried (MgSO4), filtered and concentrated in vacuo to give the crude title compound. The product was used without any further purification.

후처리

  1. washThe organic phase was washed with water, brine
  2. dry with materialdried (MgSO4)
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-eb3c9c38724444e588cf6e4b06ea2a11
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293772B2

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