[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone → HCID 11548643, 화합물

HRID 2067195노트

반응식

[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]2[N:26]=[N:27][N:28]([CH2:30][CH2:31]OC3CCCCO3)[CH:29]=2)[CH:22]=[CH:21][C:20]=1[CH3:39])=[O:18].ClC1C=C(NC2C=CC(F)=CC=2F)C=CC=1C(C1C=C(C#C)C=CC=1C)=O.N(CC[CH2:72][O:73][CH:74]1[CH2:79][CH2:78][CH2:77][CH2:76][O:75]1)=[N+]=[N-]>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2[F:16])[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([C:25]2[N:26]=[N:27][N:28]([CH2:30][CH2:31][CH2:72][O:73][CH:74]3[CH2:79][CH2:78][CH2:77][CH2:76][O:75]3)[CH:29]=2)[CH:22]=[CH:21][C:20]=1[CH3:39])=[O:18]

참가 물질

반응물 3

HCID 11706669[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(2-methyl-5-{1-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-1H-[1,2,3]triazol-4-yl}-phenyl)-methanone

HCID 58677657HCID 58677657, 화합물

HCID 866055212-(3-Azido-propoxy)-tetrahydro-pyran

생성물 1

HCID 11548643HCID 11548643, 화합물

실험 절차

The reaction was carried out similarly as described in the preparation of compound 101, using compound 407 (0.44 mmol) and compound 409 (0.44 mmol). The crude product was purified by continuous gradient flash chromatography using EtOAc/petroleum ether (40-60) 10:90 to 50:50 as the eluent to afford the title compound as colourless foam.

후처리

customThe crude product was purified by continuous gradient flash chromatography

출처 및 근거

ORD 기록: ord-8c38657d7bf04ee2a374b4ba6d07d021
출처 데이터셋: uspto-grants-2012_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08293772B2

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