[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone → [2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

HRID 2067225노트

반응식

HRID 2067225 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=2F)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:20]=1[CH3:26])=[O:18].NC1C=CC(C)=C(C(C2C=CC(NC3C=CC(F)=CC=3)=CC=2Cl)=O)C=1>>[Cl:1][C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][C:12]([F:15])=[CH:13][CH:14]=2)[CH:5]=[CH:4][C:3]=1[C:17]([C:19]1[CH:24]=[C:23]([I:25])[CH:22]=[CH:21][C:20]=1[CH3:26])=[O:18]

참가 물질

3

반응물 2

HCID 67314444[2-Chloro-4-(2,4-difluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanoneHCID 68418042(5-Amino-2-methyl-phenyl)-[2-chloro-4-(4-fluoro-phenylamino)-phenyl]-methanone

생성물 1

HCID 68421852[2-Chloro-4-(4-fluoro-phenylamino)-phenyl]-(5-iodo-2-methyl-phenyl)-methanone

실험 절차

The reaction was carried out similarly as described in the preparation of compound 405, using compound 429 (8.46 mmol). The crude product was purified by flash chromatography using EtOAc/petroleum ether (40-60) 2:8 followed by 3:7 as the eluent to afford the title compound as solid.

후처리

  1. customThe crude product was purified by flash chromatography

출처 및 근거

ORD 기록
ord-4621356e2f864caf9e7fbce6c832f793
출처 데이터셋
uspto-grants-2012_10
특허 번호
US08293772B2

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