Sodium Bicarbonate → ethyl 5-amino-3-methylthiophene-2-carboxylate
반응식
Cl.[NH2:2][C:3]1[S:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:13])[CH:4]=1.C(=O)(O)[O-].[Na+]>ClCCl>[NH2:2][C:3]1[S:7][C:6]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[C:5]([CH3:13])[CH:4]=1참가 물질
4
실험 절차
Ethyl 5-amino-3-methylthiophene-2-carboxylate hydrochloride (5.80 g, 26.2 mmol) was suspended in dichloromethane (200 mL). To the suspension was added saturated aqueous sodium bicarbonate solution (250 mL). The resulting mixture was stirred for 15 minutes, then the two layers were separated. The aqueous layer was extracted with dichloromethane (100 mL). The combined organic layer was dried over sodium sulphate, filtered and concentrated in vacuo to afford ethyl 5-amino-3-methylthiophene-2-carboxylate (4.75 g, 98%).
후처리
- customthe two layers were separated
- extractionThe aqueous layer was extracted with dichloromethane (100 mL)
- dry with materialThe combined organic layer was dried over sodium sulphate
- filtrationfiltered
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-bd89e78fa49c4d3380377d3781e175bb
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08293768B2
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