홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

1,1'-Carbonyldiimidazole → 2-(3-(2,2-dimethoxyethyl)-3-(4-fluorophenethyl)ureido)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

HRID 2067326
노트
인쇄 미리보기

반응식

HRID 2067326 반응식
[NH2:1][C:2]1[S:3][C:4]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[O:9])=[C:5]([CH3:7])[N:6]=1.[C:18](N1C=CN=C1)(N1C=CN=C1)=[O:19].[F:30][C:31]1[CH:45]=[CH:44][C:34]([CH2:35][CH2:36][NH:37][CH2:38][CH:39]([O:42][CH3:43])[O:40][CH3:41])=[CH:33][CH:32]=1>O1CCCC1>[CH3:43][O:42][CH:39]([O:40][CH3:41])[CH2:38][N:37]([CH2:36][CH2:35][C:34]1[CH:33]=[CH:32][C:31]([F:30])=[CH:45][CH:44]=1)[C:18](=[O:19])[NH:1][C:2]1[S:3][C:4]([C:8]([NH:10][CH2:11][C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[O:9])=[C:5]([CH3:7])[N:6]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 682631,1'-CarbonyldiimidazoleHCID 627938962-amino-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamideHCID 63686615N-(4-fluorophenethyl)-2,2-dimethoxyethanamine

생성물 1

HCID 866452872-(3-(2,2-dimethoxyethyl)-3-(4-fluorophenethyl)ureido)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide수율 19%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매

실험 절차

To a solution of 2-amino-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide (0.50 g, 2.01 mmol) in tetrahydrofuran (30 mL) was added 1,1% carbonyldiimidazole (0.39 g, 2.41 mmol) at ambient temperature. The resulting reaction mixture was stirred at ambient temperature for 6 hours and N-(4-fluorophenethyl)-2,2-dimethoxyethanamine (0.59 g, 2.61 mmol) was added. The reaction mixture was stirred for 17 hour at ambient temperature. The solvent was removed in vacuo, and the residue was purified by column chromatography eluted with dichloromethane/methanol (4/1) to afford 2-(3-(2,2-dimethoxyethyl)-3-(4-fluorophenethyl)ureido)-4-methyl-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide as an oil in 19% yield (0.19 g): MS (ES+) m/z 502.4 (M+1).

후처리

  1. customThe resulting reaction mixture
  2. stirringThe reaction mixture was stirred for 17 hour at ambient temperature
  3. customThe solvent was removed in vacuo
  4. customthe residue was purified by column chromatography
  5. washeluted with dichloromethane/methanol (4/1)

출처 및 근거

ORD 기록
ord-376874ebb2e0499b8457498a45deaef7
출처 데이터셋
uspto-grants-2012_10
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08293768B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트