1-(Bromomethyl)-4-(trifluoromethyl)benzene → Ethyl 4-methyl-2-(2-oxo-3-((5-phenyloxazol-4-yl)methyl)imidazolidin-1-yl)thiazole-5-carboxylate
반응식
FC(F)(F)C1C=CC(CBr)=CC=1.Br[CH2:14][C:15]1[N:16]=[CH:17][O:18][C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[CH3:26][C:27]1[N:28]=[C:29]([N:37]2[CH2:41][CH2:40][NH:39][C:38]2=[O:42])[S:30][C:31]=1[C:32]([O:34][CH2:35][CH3:36])=[O:33]>>[CH3:26][C:27]1[N:28]=[C:29]([N:37]2[CH2:41][CH2:40][N:39]([CH2:14][C:15]3[N:16]=[CH:17][O:18][C:19]=3[C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=3)[C:38]2=[O:42])[S:30][C:31]=1[C:32]([O:34][CH2:35][CH3:36])=[O:33]참가 물질
4
실험 절차
Following the procedure as described in Example 13, making variations as required to replace 4-(trifluoromethyl)benzyl bromide with 4-(bromomethyl)-5-phenyloxazole to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained as a colorless solid in 81% yield: MS (ES+) m/z 413.1 (M+1).
출처 및 근거
- ORD 기록
- ord-f198770936b44e2e8b6846acdbd8e7fc
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08293768B2
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