Piperidine → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(piperidin-1-yl)pentyloxy)-2H-chromen-2-one
반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][O:13][C:14]1[C:15]([O:34][CH3:35])=[CH:16][CH:17]=[C:18]2[C:23]=1[O:22][C:21](=[O:24])[CH:20]=[C:19]2[NH:25][C:26]1[C:31]([Cl:32])=[CH:30][N:29]=[CH:28][C:27]=1[Cl:33]>>[Cl:33][C:27]1[CH:28]=[N:29][CH:30]=[C:31]([Cl:32])[C:26]=1[NH:25][C:19]1[C:18]2[C:23](=[C:14]([O:13][CH2:12][CH2:11][CH2:10][CH2:9][CH2:8][N:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[C:15]([O:34][CH3:35])=[CH:16][CH:17]=2)[O:22][C:21](=[O:24])[CH:20]=1참가 물질
3
실험 절차
The title compound was prepared from piperidine and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6): δ 9.31 (br s, 1H), 8.55 (s, 2H), 7.85 (d, 1H), 7.04 (d, 1H), 4.20 (br s, 1H), 3.96 (t, 2H), 3.87 (s, 3H), 2.90-2.30 (br, 6H), 1.75-1.35 (m, 12H); MS (ESI): 505.9.
출처 및 근거
- ORD 기록
- ord-0d2f674480da44f68e362539eb2fb3ec
- 출처 데이터셋
- uspto-grants-2010_06
- 특허 번호
- US07745646B2
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