Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pyrrolidine → 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(pyrrolidin-1-yl)pentyloxy)-2H-chromen-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 8-(5-Bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one | HCID 24849569 | — |
| 생성물 | 4-(3,5-Dichloropyridin-4-ylamino)-7-methoxy-8-(5-(pyrrolidin-1-yl)pentyloxy)-2H-chromen-2-one | HCID 24849799 | — |
반응 단계
The title compound was prepared from pyrrolidine and 8-(5-bromopentyloxy)-4-(3,5-dichloropyridin-4-ylamino)-7-methoxy-2H-chromen-2-one (Example 28) following the procedure outlined in Example 52. 1H NMR (400 MHz, DMSO-d6): δ 9.58 (br s, 1H), 8.50 (s, 2H), 7.83 (d, 1H), 7.02 (d, 1H), 4.12 (br s, 1H), 3.97 (t, 2H), 3.87 (s, 3H), 2.87 (br, 6H), 1.80 (m, 4H), 1.70 (m, 4H), 1.53 (m, 2H); MS (ESI): 491.9.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07745646B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-d2d8b74b53fb49fbbce01643d2f12f0d |
| 출처 메모 | uspto-grants-2010_06 |