8-Cyclohexyl-2,8-diazaspiro[4.5]decane → 8-cyclohexyl-2-(4-{3-(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)-2-[(1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)methyl]propoxy}benzoyl)-2,8-diazaspiro[4.5]decane
반응식
[CH3:1][Si:2]([CH3:40])([CH3:39])[CH2:3][CH2:4][O:5][CH2:6][N:7]1[CH:11]=[CH:10][N:9]=[C:8]1[CH2:12][CH:13]([CH2:25][C:26]1[N:27]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:28]=[CH:29][N:30]=1)[CH2:14][O:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=1.[CH:41]1([N:47]2[CH2:56][CH2:55][C:50]3([CH2:54][NH:53][CH2:52][CH2:51]3)[CH2:49][CH2:48]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH:41]1([N:47]2[CH2:48][CH2:49][C:50]3([CH2:54][N:53]([C:20](=[O:21])[C:19]4[CH:23]=[CH:24][C:16]([O:15][CH2:14][CH:13]([CH2:12][C:8]5[N:7]([CH2:6][O:5][CH2:4][CH2:3][Si:2]([CH3:1])([CH3:39])[CH3:40])[CH:11]=[CH:10][N:9]=5)[CH2:25][C:26]5[N:27]([CH2:31][O:32][CH2:33][CH2:34][Si:35]([CH3:38])([CH3:37])[CH3:36])[CH:28]=[CH:29][N:30]=5)=[CH:17][CH:18]=4)[CH2:52][CH2:51]3)[CH2:55][CH2:56]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1참가 물질
3
반응물 2
생성물 1
실험 절차
Except for using the compound (50 mg) produced in Example 103 in place of the compound produced in Example 68 and using 8-cyclohexyl-2,8-diazaspiro[4.5]decane (38 mg) in place of the compound produced in Example 91, the same operation as in Example 92 was performed to obtain the title compound (54 mg) having the following physical properties.
출처 및 근거
- ORD 기록
- ord-8e0dfcae96234891804cb41c116559b1
- 출처 데이터셋
- uspto-grants-2012_10
- 특허 번호
- US08293896B2
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